Rabbit anti-Human HARS Polyclonal Antibody

The antibody against HARS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human HARS (NP_002100.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01882A

Number

Cat.No	ADA-01882A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	HARS
Target Synonyms	HRS; HARS; CMT2W; USH3B	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, MCF7, NCI-H460, U-251MG	Application	ELISA, WB

Cat.No

ADA-01882A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

HARS

Target Synonyms

HRS; HARS; CMT2W; USH3B

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, MCF7, NCI-H460, U-251MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human HARS (NP_002100.2).	Target Species	Human
Immunogen Sequence	MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG	Uniprot ID	P12081

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human HARS (NP_002100.2).

Target Species

Human

Immunogen Sequence

MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG

Uniprot ID

P12081

Background Information

Uniprot Id

P12081
Target Species

Human
Target Name

HARS1
Target Full Name

Histidine--tRNA ligase, cytoplasmic
Target Function

Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
Target Involvement

Usher syndrome 3B (USH3B); Charcot-Marie-Tooth disease 2W (CMT2W)
Target Subcellular Location

Cytoplasm.
Target Protein Families

Class-II aminoacyl-tRNA synthetase family
Target Tissue Specificity

Brain, heart, liver and kidney.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

cytoplasmic; EC 6.1.1.21 ; FLJ20491 ; HARS; HisRS; Histidine tRNA ligase, cytoplasmic; histidine translase; Histidine tRNA ligase; Histidine--tRNA ligase; Histidyl tRNA synthetase ; Histidyl-tRNA synthetase; HRS ; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds; SYHC_HUMAN; USH3B
Target Background

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human HARS Polyclonal Antibody

Specifications

Immunogen Information

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