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The antibody against HCCS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-268 of human HCCS (NP_005324.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against HCCS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-268 of human HCCS (NP_005324.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-02471A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HCCS |
| Target Synonyms | MLS; CCHL; MCOPS7; LSDMCA1; HCCS | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, HepG2, MCF7, Mouse small intestine, SKOV3, SW480 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-268 of human HCCS (NP_005324.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P53701 | Immunogen Sequence |
Uniprot Id
P53701
Target Species
Human
Target Name
HCCS
Target Full Name
Holocytochrome c-type synthase
Target Function
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
Target Involvement
Linear skin defects with multiple congenital anomalies 1 (LSDMCA1)
Target Subcellular Location
Mitochondrion inner membrane. Membrane; Lipid-anchor.
Target Protein Families
Cytochrome c-type heme lyase family
Target Research Area
Cardiovascular
Target Synonyms
CCHL; CCHL_HUMAN; cytochrome c heme-lyase; Cytochrome c-type heme lyase; DKFZp779I1858; EC 4.4.1.17; Hccs; Holocytochrome c synthase (cytochrome c heme lyase) ; Holocytochrome c synthase; Holocytochrome c type synthase ; Holocytochrome c-type synthase; MCOPS7 ; OTTHUMP00000022903; OTTHUMP00000022904; OTTHUMP00000022905; OTTMUSP00000021173; OTTMUSP00000021174; RGD1563855; RP23-37L2.1
Target Background
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.
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