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The antibody against HES6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human HES6 (NP_061115.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HES6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human HES6 (NP_061115.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00215A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HES6 |
| Target Synonyms | HES-6; bHLHb41; bHLHc23; C-HAIRY1; HES6 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human HES6 (NP_061115.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96HZ4 | Immunogen Sequence |
Uniprot Id
Q96HZ4
Target Species
Human
Target Name
HES6
Target Full Name
Transcription cofactor HES-6
Target Function
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
Target Subcellular Location
Nucleus.
Target Synonyms
HES6; BHLHB41; Transcription cofactor HES-6; C-HAIRY1; Class B basic helix-loop-helix protein 41; bHLHb41; Hairy and enhancer of split 6
Target Background
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.
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