Rabbit anti-Human HEXIM1 Monoclonal Antibody

The antibody against HEXIM1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 255-359 of human HEXIM1(NP_006451.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, IP, ELISA.

ADA-15688A

Number

Cat.No	ADA-15688A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	HEXIM1
Target Synonyms	CLP1; EDG1; HIS1; MAQ1; HEXIM1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T	Application	ELISA, WB, IF/ICC, IHC-P, IP

Cat.No

ADA-15688A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

HEXIM1

Target Synonyms

CLP1; EDG1; HIS1; MAQ1; HEXIM1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T

Application

ELISA, WB, IF/ICC, IHC-P, IP

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 255-359 of human HEXIM1(NP_006451.1).	Target Species	Human
Immunogen Sequence	MGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD	Uniprot ID	O94992

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 255-359 of human HEXIM1(NP_006451.1).

Target Species

Human

Immunogen Sequence

MGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

Uniprot ID

O94992

Background Information

Uniprot Id

O94992
Target Species

Human
Target Name

HEXIM1
Target Full Name

Protein HEXIM1
Target Function

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Target Subcellular Location

Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050).
Target Protein Families

HEXIM family
Target Tissue Specificity

Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
Target Synonyms

Cardiac lineage protein 1; CLP 1; CLP1; EDG 1; EDG1; Estrogen down-regulated gene 1 protein; FLJ13562; Hexamethylene bis acetamide inducible 1; Hexamethylene bis acetamide inducible protein; Hexamethylene bis acetamide inducible transcript 1; Hexamethylene bis-acetamide-inducible protein 1; HEXI1_HUMAN; HEXIM 1; Hexim1; HEXIM1 protein; HIS 1; HIS1; HMBA inducible ; MAQ 1; MAQ1; Menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1
Target Background

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.

Rabbit anti-Human HEXIM1 Monoclonal Antibody

Specifications

Immunogen Information

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