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The antibody against HEXIM2 was raised in rabbit using the Recombinant Human Protein HEXIM2 protein (1-286AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against HEXIM2 was raised in rabbit using the Recombinant Human Protein HEXIM2 protein (1-286AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-21999A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HEXIM2 |
| Target Synonyms | Hexamethylene bis-acetamide-inducible protein 2 antibody; Hexamthylene bis-acetamide inducible 2 antibody; HEXI2_HUMAN antibody; hexim 2 antibody; HEXIM2 antibody; L3 antibody; Protein HEXIM2 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein HEXIM2 protein (1-286AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96MH2 |
Uniprot Id
Q96MH2
Target Species
Human
Target Name
HEXIM2
Target Full Name
Protein HEXIM2
Target Function
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Target Subcellular Location
Nucleus.
Target Protein Families
HEXIM family
Target Tissue Specificity
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
Target Research Area
Transcription
Target Synonyms
Hexamethylene bis-acetamide-inducible protein 2; Hexamthylene bis-acetamide inducible 2 ; HEXI2_HUMAN; hexim 2; HEXIM2; L3; Protein HEXIM2
Target Background
This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants.
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