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The antibody against HFE was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-306 of human HFE (NP_000401.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HFE was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 80-306 of human HFE (NP_000401.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09582A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HFE |
| Target Synonyms | HH; HFE1; HLA-H; MVCD7; TFQTL2; HFE | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 80-306 of human HFE (NP_000401.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q30201 | Immunogen Sequence |
Uniprot Id
Q30201
Target Species
Human
Target Name
HFE
Target Full Name
Hereditary hemochromatosis protein
Target Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Target Involvement
Hemochromatosis 1 (HFE1); Variegate porphyria (VP); Microvascular complications of diabetes 7 (MVCD7)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
MHC class I family
Target Tissue Specificity
Expressed in all tissues tested except brain.
Target Research Area
Metabolism
Target Synonyms
dJ221C16.10.1; Hemochromatosis; Hemochromatosis protein; Hereditary hemochromatosis protein; Hereditary hemochromatosis protein HLA H; HFE 1; HFE; HFE_HUMAN; HFE1; HH; High Fe; HLA H; HLA-H; HLAH; MGC:150812; MGC10379; MGC103790; MHC class I like protein HFE; MVCD7; TFQTL2
Target Background
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.
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