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The antibody against HIP1R was raised in rabbit using the Recombinant Human Huntingtin-interacting protein 1-related protein (304-487AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against HIP1R was raised in rabbit using the Recombinant Human Huntingtin-interacting protein 1-related protein (304-487AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-06900A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HIP1R |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Huntingtin-interacting protein 1-related protein (304-487AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75146 |
Uniprot Id
O75146
Target Species
Human
Target Name
HIP1R
Target Full Name
Huntingtin-interacting protein 1-related protein
Target Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Target Subcellular Location
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Target Protein Families
SLA2 family
Target Tissue Specificity
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
Target Synonyms
FLJ14000; FLJ27022; HIP-12; Hip1 related ; HIP1-related protein; HIP12; HIP1R; HIP1R_HUMAN; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; ILWEQ; KIAA0655; MGC47513
Target Background
Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3, 4-bisphosphate binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; protein stabilization; and regulation of organelle organization. Located in clathrin-coated vesicle; cytosol; and ruffle membrane.
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