Rabbit anti-Human HIST1H1A Polyclonal Antibody

Uniprot Id

Q02539

Target Species

Human

Target Name

H1-1

Target Full Name

Histone H1.1

Target Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.

Target Subcellular Location

Nucleus. Chromosome. Note=Mainly localizes in euchromatin.

Target Protein Families

Histone H1/H5 family

Target Synonyms

H1A; H1.1; H1F1; HIST1; HIST1H1A

Target Background

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.