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The antibody against HMBOX1 was raised in rabbit using the Human HMBOX1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against HMBOX1 was raised in rabbit using the Human HMBOX1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-53122A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HMBOX1 |
| Target Synonyms | HMBOX1 antibody; HOT1 antibody; TAH1 antibody; Homeobox-containing protein 1 antibody; Homeobox telomere-binding protein 1 antibody; Telomere-associated homeobox-containing protein 1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human HMBOX1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6NT76 |
Uniprot Id
Q6NT76
Target Species
Human
Target Name
HMBOX1
Target Full Name
Homeobox-containing protein 1
Target Function
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
Target Subcellular Location
Nucleus. Cytoplasm. Chromosome, telomere. Nucleus, Cajal body. Nucleus, PML body.; [Isoform 5]: Nucleus. Cytoplasm.
Target Tissue Specificity
Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, colon, lung, cardiac muscle and thyroid gland.
Target Synonyms
HMBOX1; HOT1; TAH1; Homeobox-containing protein 1; Homeobox telomere-binding protein 1; Telomere-associated homeobox-containing protein 1
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