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The antibody against HOMER3 was raised in rabbit using the Recombinant Human Homer protein homolog 3 protein (151-361AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against HOMER3 was raised in rabbit using the Recombinant Human Homer protein homolog 3 protein (151-361AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-22669A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HOMER3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Homer protein homolog 3 protein (151-361AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NSC5 |
Uniprot Id
Q9NSC5
Target Species
Human
Target Name
HOMER3
Target Full Name
Homer protein homolog 3
Target Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Target Subcellular Location
Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
Target Protein Families
Homer family
Target Synonyms
HOME3_HUMAN; HOMER 3; Homer 3D protein ; Homer homolog 3 (Drosophila); Homer neuronal immediate early gene 3; Homer protein homolog 3; Homer-3; Homer3; VESL3
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