Rabbit anti-Human HOXC11 Polyclonal Antibody

Uniprot Id

O43248

Target Species

Human

Target Name

HOXC11

Target Full Name

Homeobox protein Hox-C11

Target Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Target Subcellular Location

Nucleus.

Target Protein Families

Abd-B homeobox family

Target Synonyms

Homeo box C11; Homeobox C11; Homeobox protein Hox C11; Homeobox protein Hox-3H; Homeobox protein Hox-C11; HOX3H; HOXC11; HXC11_HUMAN; MGC4906

Target Background

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.