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The antibody against HPS5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 340-600 of human HPS5 (NP_009147.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HPS5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 340-600 of human HPS5 (NP_009147.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02156A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HPS5 |
| Target Synonyms | AIBP63; BLOC2S2; HPS5 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, B cells, Jurkat | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 340-600 of human HPS5 (NP_009147.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UPZ3 | Immunogen Sequence |
Uniprot Id
Q9UPZ3
Target Species
Human
Target Name
HPS5
Target Full Name
BLOC-2 complex member HPS5
Target Function
May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.
Target Involvement
Hermansky-Pudlak syndrome 5 (HPS5)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
HPS5 family
Target Tissue Specificity
Widely expressed. Isoform 1:Highly expressed in lungs and testis. Isoform 2:Highly expressed in placenta, kidney, testis ovary, lung and thymus.
Target Synonyms
HPS5; AIBP63; KIAA1017; Hermansky-Pudlak syndrome 5 protein; Alpha-integrin-binding protein 63; Ruby-eye protein 2 homolog; Ru2
Target Background
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5. Multiple transcript variants encoding two distinct isoforms have been identified for this gene.
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