Rabbit anti-Human HRSP12 Polyclonal Antibody

Uniprot Id

P52758

Target Species

Human

Target Name

RIDA

Target Full Name

2-iminobutanoate/2-iminopropanoate deaminase

Target Function

Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.

Target Subcellular Location

Cytoplasm. Nucleus. Peroxisome. Mitochondrion.

Target Protein Families

RutC family

Target Tissue Specificity

Expressed predominantly in liver and kidney. Lower levels in lung and brain.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; Heat responsive protein 12; Heat-responsive protein 12; Hrsp12; p14.5; Perchloric acid soluble protein; PSP; Reactive intermediate imine deaminase A homolog; Ribonuclease UK114; RIDA; Translational inhibitor p14.5; Translational inhibitor protein p14.5; UK114; UK114 antigen homolog; UK114_HUMAN

Target Background

Enables 2-iminobutanoate deaminase activity and mRNA binding activity. Involved in mRNA catabolic process; mRNA destabilization; and organonitrogen compound catabolic process. Located in cytoplasm and nucleus.