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The antibody against HSD3B7 was raised in rabbit using the Recombinant Human 3 beta-hydroxysteroid dehydrogenase type 7 protein (131-197AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against HSD3B7 was raised in rabbit using the Recombinant Human 3 beta-hydroxysteroid dehydrogenase type 7 protein (131-197AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
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| Cat.No | ADC-09519A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HSD3B7 |
| Target Synonyms | 7-alpha-diol 3-beta-dehydrogenase | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | FITC conjugated | Storage | Upon receipt |
| Immunogen Description | Recombinant Human 3 beta-hydroxysteroid dehydrogenase type 7 protein (131-197AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H2F3 |
Uniprot Id
Q9H2F3
Target Species
Human
Target Name
HSD3B7
Target Full Name
3 beta-hydroxysteroid dehydrogenase type 7
Target Function
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Target Involvement
Congenital bile acid synthesis defect 1 (CBAS1)
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
3-beta-HSD family
Target Synonyms
HSD3B7; 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5-C27 steroid oxidoreductase; C(27 3-beta-HSD; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
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