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The antibody against HTATSF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HTATSF1 (NP_055315.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against HTATSF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HTATSF1 (NP_055315.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-03612A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HTATSF1 |
| Target Synonyms | TATSF1; TAT-SF1; dJ196E23.2; HTATSF1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Jurkat, U-251MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human HTATSF1 (NP_055315.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43719 | Immunogen Sequence |
Uniprot Id
O43719
Target Species
Human
Target Name
HTATSF1
Target Full Name
17S U2 SnRNP complex component HTATSF1
Target Function
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.
Target Subcellular Location
Nucleus.
Target Protein Families
HTATSF1 family
Target Tissue Specificity
Widely expressed.
Target Synonyms
HTATSF1HIV Tat-specific factor 1; Tat-SF1
Target Background
The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.
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