Rabbit anti-Human HTRA3 Polyclonal Antibody

The antibody against HTRA3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11416A

Number

Cat.No	ADA-11416A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	HTRA3
Target Synonyms	Prsp; Tasp; HTRA3	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, Mouse brain, SKOV3	Application	ELISA, WB

Cat.No

ADA-11416A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

HTRA3

Target Synonyms

Prsp; Tasp; HTRA3

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, Mouse brain, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1).	Target Species	Human
Immunogen Sequence	SDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM	Uniprot ID	P83110

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1).

Target Species

Human

Immunogen Sequence

SDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM

Uniprot ID

P83110

Background Information

Uniprot Id

P83110
Target Species

Human
Target Name

HTRA3
Target Full Name

Serine protease HTRA3
Target Function

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Target Subcellular Location

Secreted. Note=Secretion increased during decidualization of endometrial stromal cells.
Target Protein Families

Peptidase S1C family
Target Tissue Specificity

Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle,
Target Synonyms

High temperature requirement factor A3; High-temperature requirement factor A3; HtrA serine peptidase 3; HTRA3; HTRA3_HUMAN; Pregnancy related serine protease; Pregnancy-related serine protease; Probable serine protease HTRA3; PRSP ; Serine protease HTRA3; Tasp
Target Background

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region.

Rabbit anti-Human HTRA3 Polyclonal Antibody

Specifications

Immunogen Information

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