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The antibody against Human IL-5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-134 of human IL-5 (NP_000870.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against Human IL-5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-134 of human IL-5 (NP_000870.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Western blot analysis of recombinant Human IL-5 Protein, using Human IL-5 Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 10ng/5ng per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 0.8s.
| Cat.No | ADA-07635A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Human IL-5 |
| Target Synonyms | EDF; TRF; IL-5; Human IL-5 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat, Other (Wide Range Predicted) | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Recombinant Human IL-5 Protein | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-134 of human IL-5 (NP_000870.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES | Uniprot ID | P05113 |
Uniprot Id
P05113
Target Species
Human
Target Name
IL5
Target Full Name
Interleukin-5
Target Function
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Target Subcellular Location
Secreted.
Target Protein Families
IL-5 family
Target Research Area
Immunology
Target Synonyms
B-cell differentiation factor I; Colony stimulating factor; EDF; Eosinophil differentiation factor; IL-5; IL5; IL5_HUMAN; Interleukin 5 (colony stimulating factor; eosinophil); Interleukin 5; Interleukin-5; T Cell Replacing Factor; T-cell replacing factor; TRF
Target Background
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
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