Rabbit anti-Human Human PLA2G7/PAF-AH/Lp-PLA2 Polyclonal Antibody

Uniprot Id

Q13093

Target Species

Human

Target Name

PLA2G7

Target Full Name

Platelet-activating factor acetylhydrolase

Target Function

Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells. Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects. As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall. Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage.

Target Involvement

Platelet-activating factor acetylhydrolase deficiency (PAFAD); Asthma (ASTHMA); Atopic hypersensitivity (ATOPY)

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Tissue Specificity

Plasma. Secreted by macrophages (at protein level).

Target Synonyms

PLA2G7; LDL-PLA2; LP-PLA2; PAFAD; PAFAH; phospholipase A2 group VII; Human PLA2G7/PAF-AH/Lp-PLA2

Target Background

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.