Rabbit anti-Human ICAM-1/CD54 Monoclonal Antibody

The antibody against ICAM-1/CD54 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human ICAM-1/CD54 (P05362) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, FC, ELISA.

ADA-16770A

Number

Cat.No	ADA-16770A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	ICAM-1/CD54
Target Synonyms	BB2; CD54; P3.58; MALA2; MyD10; ICAM-1/CD54	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Application	ELISA, WB, FC, IHC-P

Cat.No

ADA-16770A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

ICAM-1/CD54

Target Synonyms

BB2; CD54; P3.58; MALA2; MyD10; ICAM-1/CD54

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Application

ELISA, WB, FC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ICAM-1/CD54 (P05362).	Target Species	Human
Immunogen Sequence	MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQ	Uniprot ID	P05362

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ICAM-1/CD54 (P05362).

Target Species

Human

Immunogen Sequence

MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQ

Uniprot ID

P05362

Background Information

Uniprot Id

P05362
Target Species

Human
Target Name

ICAM1
Target Full Name

Intercellular adhesion molecule 1
Target Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.; (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.; (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.; (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Protein Families

Immunoglobulin superfamily, ICAM family
Target Research Area

Cell Adhesion
Target Synonyms

Antigen identified by monoclonal BB2; BB 2; BB2; CD 54; CD_antigen=CD54; CD54; Cell surface glycoprotein P3.58 ; Human rhinovirus receptor; ICAM 1; ICAM-1; ICAM1; ICAM1_HUMAN; intercellular adhesion molecule 1 (CD54); intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA 2; MALA2; MyD 10; MyD10; P3.58; Surface antigen of activated B cells; Surface antigen of activated B cells, BB2
Target Background

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.

Rabbit anti-Human ICAM-1/CD54 Monoclonal Antibody

Specifications

Immunogen Information

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