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The antibody against ICAM3 was raised in rabbit using the Recombinant Human Intercellular adhesion molecule 3 protein (200-547aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against ICAM3 was raised in rabbit using the Recombinant Human Intercellular adhesion molecule 3 protein (200-547aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Western Blot | Positive WB detected in: L02 whole cell lysate, PC-3 whole cell lysate, U87 whole cell lysate, HepG2 whole cell lysate | All lanes: ICAM3 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 60 kDa | Observed band size: 60 kDa
| Cat.No | ADC-55069A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ICAM3 |
| Target Synonyms | ICAM3; Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R; CD antigen CD50 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Intercellular adhesion molecule 3 protein (200-547aa) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P32942 |
Uniprot Id
P32942
Target Species
Human
Target Name
ICAM3
Target Full Name
Intercellular adhesion molecule 3
Target Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Immunoglobulin superfamily, ICAM family
Target Tissue Specificity
Leukocytes.
Target Synonyms
ICAM3; Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R; CD antigen CD50
Target Background
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
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