Rabbit anti-Human ICAM4 Polyclonal Antibody

Uniprot Id

Q14773

Target Species

Human

Target Name

ICAM4

Target Full Name

Intercellular adhesion molecule 4

Target Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Target Subcellular Location

[Isoform Long]: Cell membrane; Single-pass type I membrane protein.; [Isoform Short]: Secreted.; Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, ICAM family

Target Tissue Specificity

Erythrocytes.

Target Synonyms

CD242; CD242 antigen ; ICAM-4; Icam4; ICAM4_HUMAN; Intercellular adhesion molecule 4; Landsteiner Wiener blood group glycoprotein; Landsteiner-Wiener blood group glycoprotein; LW; LW blood group protein

Target Background

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.