Rabbit anti-Human ICE2 Polyclonal Antibody

The antibody against ICE2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human ICE2 (NP_078887.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03300A

Number

Cat.No	ADA-03300A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ICE2
Target Synonyms	BRCC1; NARG2; ICE2	Form	Liquid
Species Reactivity	Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse brain	Application	ELISA, WB

Cat.No

ADA-03300A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ICE2

Target Synonyms

BRCC1; NARG2; ICE2

Form

Liquid

Species Reactivity

Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse brain

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human ICE2 (NP_078887.2).	Target Species	Human
Immunogen Sequence	SRKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQACYGVEALTESELCRLWTESLL	Uniprot ID	Q659A1

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human ICE2 (NP_078887.2).

Target Species

Human

Immunogen Sequence

SRKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQACYGVEALTESELCRLWTESLL

Uniprot ID

Q659A1

Background Information

Uniprot Id

Q659A1
Target Species

Human
Target Name

ICE2
Target Full Name

Little elongation complex subunit 2
Target Function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Target Subcellular Location

Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Target Protein Families

ICE2 family
Target Tissue Specificity

Expressed at low levels in lung and testis.
Target Synonyms

ICE2; BRCC1; NARG2; UNQ3101/PRO10100; Little elongation complex subunit 2; Interactor of little elongator complex ELL subunit 2; NMDA receptor-regulated protein 2
Target Background

This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4.

Rabbit anti-Human ICE2 Polyclonal Antibody

Specifications

Immunogen Information

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