Rabbit anti-Human IDH2 Monoclonal Antibody

The antibody against IDH2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 353-452 of human IDH2 (P48735) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-15807A

Number

Cat.No	ADA-15807A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	IDH2
Target Synonyms	IDH; IDP; IDHM; IDPM; ICD-M; IDH-2; D2HGA2; mNADP-IDH; IDH2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HepG2, K-562, Mouse liver, Rat liver	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-15807A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

IDH2

Target Synonyms

IDH; IDP; IDHM; IDPM; ICD-M; IDH-2; D2HGA2; mNADP-IDH; IDH2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, K-562, Mouse liver, Rat liver

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 353-452 of human IDH2 (P48735).	Target Species	Human
Immunogen Sequence	RHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ	Uniprot ID	P48735

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 353-452 of human IDH2 (P48735).

Target Species

Human

Immunogen Sequence

RHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ

Uniprot ID

P48735

Background Information

Uniprot Id

P48735
Target Species

Human
Target Name

IDH2
Target Full Name

Isocitrate dehydrogenase [NADP], mitochondrial
Target Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Target Involvement

D-2-hydroxyglutaric aciduria 2 (D2HGA2); Glioma (GLM)
Target Subcellular Location

Mitochondrion.
Target Protein Families

Isocitrate and isopropylmalate dehydrogenases family
Target Synonyms

D2HGA2; ICD-M; IDH; IDH2; IDHM; IDHP_HUMAN; IDP; IDPM; Isocitrate dehydrogenase [NADP], mitochondrial; Isocitrate dehydrogenase 2 (NADP+), mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
Target Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human IDH2 Monoclonal Antibody

Specifications

Immunogen Information

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