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The antibody against IFI30 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IFI30 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03365A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IFI30 |
| Target Synonyms | GILT; IP30; IP-30; IFI-30; IFI30 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-431, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P13284 | Immunogen Sequence |
Uniprot Id
P13284
Target Species
Human
Target Name
IFI30
Target Full Name
Gamma-interferon-inducible lysosomal thiol reductase
Target Function
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
Target Subcellular Location
Secreted. Lysosome.
Target Protein Families
GILT family
Target Research Area
Immunology
Target Synonyms
Gamma interferon inducible lysosomal thiol reductase; Gamma interferon inducible protein IP 30 ; Gamma-interferon-inducible lysosomal thiol reductase; Gamma-interferon-inducible protein IP-30; GILT ; GILT_HUMAN; IFI 30; IFI30; interferon gamma inducible protein 30; Interferon gamma inducible protein 30 preproprotein ; IP30 ; Legumaturain; Lysosomal thiol reductase; Lysosomal thiol reductase; gamma-interferon-inducible
Target Background
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.
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