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The antibody against IFT57 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IFT57 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02635A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IFT57 |
| Target Synonyms | HIPPI; OFD18; MHS4R2; ESRRBL1; IFT57 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, HL-60, HT-29, MCF7, Mouse brain, Mouse testis, Rat lung, U-937 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NWB7 | Immunogen Sequence |
Uniprot Id
Q9NWB7
Target Species
Human
Target Name
IFT57
Target Full Name
Intraflagellar transport protein 57 homolog
Target Function
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Target Subcellular Location
Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
IFT57 family
Target Tissue Specificity
Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
Target Synonyms
CDNA FLJ10147 fis clone HEMBA1003369; Dermal papilla derived protein 8; Dermal papilla-derived protein 8; DERP 8; DERP8; Esrrbl 1; Esrrbl1; ESRRBL1 protein; Estrogen related receptor beta like 1; Estrogen related receptor beta like protein 1; Estrogen-related receptor beta-like protein 1; FLJ10147; Hip1 Interacting protein; HIP1 interacting protein HIPPI; Hip1 protein interactor; HIP1-interacting protein; HIPPI; Huntingtin interacting protein 1 interacting protein; Huntingtin interacting protein 1 protein interactor; IFT 57; ift57; IFT57_HUMAN; Intraflagellar transport 57 homolog (Chlamydomonas); Intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2; Vestrogen related receptor beta like 1
Target Background
Predicted to enable DNA binding activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; and regulation of apoptotic process. Predicted to be located in ciliary basal body. Predicted to be part of axoneme and intraciliary transport particle B. Predicted to be active in Golgi apparatus; centrosome; and cilium. Implicated in orofaciodigital syndrome.
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