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Rabbit anti-Human IGFBP1 Polyclonal Antibody

The antibody against IGFBP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 150-250 of human IGFBP1 (NP_000587.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11732A

The antibody against IGFBP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 150-250 of human IGFBP1 (NP_000587.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-11732A ClonalityPolyclonal
Host SpeciesRabbitTarget NameIGFBP1
Target SynonymsAFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; IGFBP1FormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.05% proclin300, pH7.3.Purification MethodAffinity purification
Positive SamplesHepG2ApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 150-250 of human IGFBP1 (NP_000587.1).Target SpeciesHuman
Immunogen SequenceILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNUniprot IDP08833
Background Information
  • Uniprot Id

    P08833

  • Target Species

    Human

  • Target Name

    IGFBP1

  • Target Full Name

    Insulin-like growth factor-binding protein 1

  • Target Function

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

  • Target Subcellular Location

    Secreted.

  • Target Synonyms

    AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; IGFBP1

  • Target Background

    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.

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