Rabbit anti-Human IGKC Polyclonal Antibody

Uniprot Id

P01834

Target Species

Human

Target Name

IGKC

Target Full Name

Immunoglobulin kappa constant

Target Function

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.

Target Involvement

Immunoglobulin kappa light chain deficiency (IGKCD)

Target Subcellular Location

Secreted. Cell membrane.

Target Synonyms

Km; HCAK1; IGKCD; Human Ig Kappa Chain

Target Background

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in retina homeostasis. Located in blood microparticle and extracellular exosome.