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The antibody against IL-31 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL-31 (NP_001014358.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against IL-31 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL-31 (NP_001014358.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Western blot analysis of recombinant Human IL-31 Protein, using IL-31 Rabbit mAb at 1:4000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 5ng per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
| Cat.No | ADA-15504A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL-31 |
| Target Synonyms | IL-31 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Recombinant Human IL-31 Protein | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 24-164 of human IL-31 (NP_001014358.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT | Uniprot ID | Q6EBC2 |
Uniprot Id
Q6EBC2
Target Species
Human
Target Name
IL31
Target Full Name
Interleukin-31
Target Function
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages.
Target Subcellular Location
Secreted.
Target Tissue Specificity
Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Target Research Area
Immunology
Target Synonyms
IL 31; IL-31; IL31; IL31_HUMAN; Interleukin 31; Interleukin-31
Target Background
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).
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