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The antibody against IL1RL1 was raised in rabbit using the Recombinant Human Interleukin-1 receptor-like 1 protein (19-328AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against IL1RL1 was raised in rabbit using the Recombinant Human Interleukin-1 receptor-like 1 protein (19-328AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49781A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL1RL1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Interleukin-1 receptor-like 1 protein (19-328AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q01638 |
Uniprot Id
Q01638
Target Species
Human
Target Name
IL1RL1
Target Full Name
Interleukin-1 receptor-like 1
Target Function
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.; Inhibits IL-33 signaling.
Target Subcellular Location
[Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Interleukin-1 receptor family
Target Tissue Specificity
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C
Target Synonyms
T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R; IL1RL1
Target Background
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
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