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The antibody against IL22RA2 was raised in rabbit using the Recombinant Human Interleukin-22 receptor subunit alpha-2 protein (22-231AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against IL22RA2 was raised in rabbit using the Recombinant Human Interleukin-22 receptor subunit alpha-2 protein (22-231AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using IL22RA2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using IL22RA2 Antibody at dilution of 1:1002
| Cat.No | ADC-17364A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL22RA2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Interleukin-22 receptor subunit alpha-2 protein (22-231AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q969J5 |
Uniprot Id
Q969J5
Target Species
Human
Target Name
IL22RA2
Target Full Name
Interleukin-22 receptor subunit alpha-2
Target Function
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Target Subcellular Location
Secreted.
Target Protein Families
Type II cytokine receptor family
Target Tissue Specificity
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placen
Target Synonyms
IL 22BP; IL 22RA2; IL22RA2; Class II cytokine receptor; CRF2 10; CRF2 S1; CRF2-10; CRF2-S1; CRF2X; Cytokine receptor class II member 10; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2; Cytokine receptor family type 2 soluble 1; I22R2_HUMAN; IL 22 receptor subunit alpha 2; IL 22R alpha 2; IL-22 receptor subunit alpha-2; IL-22BP; IL-22R-alpha-2; IL-22RA2; IL22 RA2; IL22BP; IL22R alpha 2; Il22ra2; Interleukin 22 binding protein; Interleukin 22 Receptor alpha 2; Interleukin-22 receptor subunit alpha-2; Interleukin-22-binding protein; MGC150509; MGC150510; soluble 1; ZcytoR16
Target Background
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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