Rabbit anti-Human IL23R Polyclonal Antibody

The antibody against IL23R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 510-629 of human IL23R (NP_653302.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-09999A

Number

Cat.No	ADA-09999A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	IL23R
Target Synonyms	PSORS7; IL23R	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	K-562	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-09999A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

IL23R

Target Synonyms

PSORS7; IL23R

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

K-562

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 510-629 of human IL23R (NP_653302.2).	Target Species	Human
Immunogen Sequence	KPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK	Uniprot ID	Q5VWK5

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 510-629 of human IL23R (NP_653302.2).

Target Species

Human

Immunogen Sequence

KPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK

Uniprot ID

Q5VWK5

Background Information

Uniprot Id

Q5VWK5
Target Species

Human
Target Name

IL23R
Target Full Name

Interleukin-23 receptor
Target Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Target Involvement

Inflammatory bowel disease 17 (IBD17)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Protein Families

Type I cytokine receptor family, Type 2 subfamily
Target Tissue Specificity

Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Target Synonyms

IL 23R; IL-23 receptor; IL-23R; IL23 Receptor; Il23r; IL23R_HUMAN; Interleukin 23 receptor ; Interleukin-23 receptor
Target Background

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Rabbit anti-Human IL23R Polyclonal Antibody

Specifications

Immunogen Information

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