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The antibody against IL27RA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 33-283 of human IL27RA (NP_004834.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against IL27RA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 33-283 of human IL27RA (NP_004834.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-08673A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL27RA |
| Target Synonyms | CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1; IL27RA | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | MCF7, Mouse liver, Rat liver | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 33-283 of human IL27RA (NP_004834.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6UWB1 | Immunogen Sequence |
Uniprot Id
Q6UWB1
Target Species
Human
Target Name
IL27RA
Target Full Name
Interleukin-27 receptor subunit alpha
Target Function
Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Type I cytokine receptor family, Type 2 subfamily
Target Tissue Specificity
Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s
Target Synonyms
Class I cytokine receptor; CRL1; Cytokine receptor-like 1; I27RA_HUMAN; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R alpha; IL27R; Il27ra; Interleukin 27 receptor alpha chain precursor; Interleukin 27 receptor; Interleukin-27 receptor subunit alpha; Protein CRL1; T cell cytokine receptor type 1; TCCR; Type 1 T cell cytokine receptor; Type I T-cell cytokine receptor; WSX-1; WSX1; ZcytoR1
Target Background
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
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