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The antibody against IL31RA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_001284501.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against IL31RA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_001284501.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03161A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL31RA |
| Target Synonyms | CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17; IL31RA | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_001284501.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8NI17 | Immunogen Sequence |
Uniprot Id
Q8NI17
Target Species
Human
Target Name
IL31RA
Target Full Name
Interleukin-31 receptor subunit alpha
Target Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
Target Involvement
Amyloidosis, primary localized cutaneous, 2 (PLCA2)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
Target Protein Families
Type I cytokine receptor family, Type 2 subfamily
Target Tissue Specificity
Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, b
Target Synonyms
Class I cytokine receptor; CRL 3; CRL; CRL3; Cytokine receptor like 3; Cytokine receptor-like 3; GLM R; GLM-R; GLMR; Gp130 like monocyte receptor; GP130 like receptor; Gp130-like monocyte receptor; Gp130-like receptor; GPL; HGLM R; HGLM-R; HGLMR; IL 31 receptor subunit alpha; IL 31R subunit alpha; IL 31RA; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; IL31 receptor subunit alpha; IL31R subunit alpha; IL31R_HUMAN; IL31RA; Interleukin 31 receptor A; interleukin 31 receptor subunit alpha; Interleukin-31 receptor subunit alpha; MGC125346; PLCA 2; PLCA2; PRO21384; Soluble type I cytokine receptor CRL3; ZcytoR17
Target Background
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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