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The antibody against vpx was raised in rabbit using the Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against vpx was raised in rabbit using the Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-44978A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | vpx |
| Target Synonyms | vpxProtein Vpx antibody; Viral protein X antibody; X ORF protein antibody | Form | Liquid |
| Species Reactivity | Human immunodeficiency virus type 2 subtype A | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA) | Target Species | Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P18099 |
Uniprot Id
P18099
Target Species
Human immunodeficiency virus type 2 subtype A
Target Name
VPX
Target Function
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Target Subcellular Location
Virion. Host nucleus.
Target Protein Families
Lentivirus VPX protein family
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