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The antibody against IMPA1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against IMPA1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-03063A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IMPA1 |
| Target Synonyms | IMP; IMPA; MRT59; IMPA1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Jurkat, Mouse brain, Mouse liver, Rat kidney, SH-SY5Y, SKOV3, SW620 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human IMPA1 (NP_005527.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P29218 | Immunogen Sequence |
Uniprot Id
P29218
Target Species
Human
Target Name
IMPA1
Target Full Name
Inositol monophosphatase 1
Target Function
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Target Involvement
Mental retardation, autosomal recessive 59 (MRT59)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Inositol monophosphatase superfamily
Target Synonyms
IMP 1; IMP; IMPA 1; IMPA; IMPA1; IMPA1_HUMAN; IMPase 1; IMPase; Inositol 1(or 4) monophosphatase; Inositol monophosphatase 1; Inositol monophosphatase; Inositol(myo) 1(or 4) monophosphatase 1; Inositol-1(or 4)-monophosphatase 1; Lithium sensitive myo inositol monophosphatase A1; Lithium-sensitive myo-inositol monophosphatase A1
Target Background
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
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