Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against IMPACT was raised in rabbit using the Recombinant Human Protein IMPACT protein (41-320AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against IMPACT was raised in rabbit using the Recombinant Human Protein IMPACT protein (41-320AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-17805A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IMPACT |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein IMPACT protein (41-320AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9P2X3 |
Uniprot Id
Q9P2X3
Target Species
Human
Target Name
IMPACT
Target Full Name
Protein IMPACT
Target Function
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Target Subcellular Location
Cytoplasm.
Target Protein Families
IMPACT family
Target Tissue Specificity
Widely expressed. Expressed at high level in brain.
Target Synonyms
IMPACT; Impact homolog (mouse); Impact homolog; impact RWD domain protein; IMPCT_HUMAN; Imprinted and ancient gene protein homolog; MGC33718; Protein IMPACT; RWD domain containing 5; RWDD5
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
