Rabbit anti-Human IMPDH1 Polyclonal Antibody

Uniprot Id

P20839

Target Species

Human

Target Name

IMPDH1

Target Full Name

Inosine-5'-monophosphate dehydrogenase 1

Target Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Target Involvement

Retinitis pigmentosa 10 (RP10); Leber congenital amaurosis 11 (LCA11)

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

IMPDH/GMPR family

Target Tissue Specificity

IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Target Synonyms

IMPD; RP10; IMPD1; LCA11; IMPDH-I; sWSS2608; IMPDH1

Target Background

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.