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The antibody against INPP4B was raised in rabbit using the Recombinant Human Type II inositol 3,4-bisphosphate 4-phosphatase protein (1-53AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against INPP4B was raised in rabbit using the Recombinant Human Type II inositol 3,4-bisphosphate 4-phosphatase protein (1-53AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-15952A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INPP4B |
| Target Synonyms | 4 bisphosphate 4 phosphatase antibody; Type II inositol-3 antibody, Inositol polyphosphate 4 phosphatase | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Type II inositol 3,4-bisphosphate 4-phosphatase protein (1-53AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15327 |
Uniprot Id
O15327
Target Species
Human
Target Name
INPP4B
Target Full Name
Inositol polyphosphate 4-phosphatase type II
Target Function
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival.
Target Protein Families
Inositol 3,4-bisphosphate 4-phosphatase family
Target Tissue Specificity
Widely expressed with highest levels occurring in the skeletal muscle and heart.
Target Synonyms
Inositol polyphosphate 4 phosphatase, type II; 4-bisphosphate 4-phosphatase; Inositol polyphosphate 4 phosphatase type II 105kDa; Inositol polyphosphate 4-phosphatase type II; INP4B_HUMAN; Inpp4b; MGC132014; Type II inositol 3,4 bisphosphate 4 phosphatase; Type II inositol-3
Target Background
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3, 4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.
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