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The antibody against INSRR was raised in rabbit using the Recombinant Human Insulin receptor-related protein (747-921AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against INSRR was raised in rabbit using the Recombinant Human Insulin receptor-related protein (747-921AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, antigen affinity purified & affinity purified with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
Western Blot | Positive WB detected in: SH-SY5Y whole cell lysate, U87 whole cell lysate, K562 whole cell lysate, MCF-7 whole cell lysatee, HepG2 whole cell lysate | All lanes: INSRR antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 144 kDa | Observed band size: 144 kDa
| Cat.No | ADC-00660A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INSRR |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Antigen Affinity purified & Affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Insulin receptor-related protein (747-921AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P14616 |
Uniprot Id
P14616
Target Species
Human
Target Name
INSRR
Target Full Name
Insulin receptor-related protein
Target Function
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Target Synonyms
INSRR; INSRR_HUMAN; Insulin Receptor R; Insulin receptor related receptor precursor; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; insulin receptor-related receptor; IR R; IR related receptor; IR-related receptor; IRR; Sir r; Sirr
Target Background
Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex.
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