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The antibody against IRF2 was raised in rabbit using the Recombinant Human Interferon regulatory factor 2 protein (120-349AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against IRF2 was raised in rabbit using the Recombinant Human Interferon regulatory factor 2 protein (120-349AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human thyroid tissue using IRF2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using IRF2 Antibody at dilution of 1:1002
Immunohistochemistry of paraffin-embedded human kidney tissue using IRF2 Antibody at dilution of 1:1003
| Cat.No | ADC-44416A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IRF2 |
| Target Synonyms | DKFZp686F0244 antibody; Interferon regulatory factor 2 antibody; IRF 2 antibody; IRF-2 antibody; IRF2 antibody; IRF2_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Interferon regulatory factor 2 protein (120-349AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P14316 |
Uniprot Id
P14316
Target Species
Human
Target Name
IRF2
Target Full Name
Interferon regulatory factor 2
Target Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Target Subcellular Location
Nucleus.
Target Protein Families
IRF family
Target Tissue Specificity
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Target Synonyms
DKFZp686F0244; Interferon regulatory factor 2; IRF 2; IRF-2; IRF2; IRF2_HUMAN
Target Background
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
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