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The antibody against IRF6 was raised in rabbit using the Recombinant Human Interferon regulatory factor 6 protein (43-285AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against IRF6 was raised in rabbit using the Recombinant Human Interferon regulatory factor 6 protein (43-285AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-12663A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IRF6 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Interferon regulatory factor 6 protein (43-285AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14896 |
Uniprot Id
O14896
Target Species
Human
Target Name
IRF6
Target Full Name
Interferon regulatory factor 6
Target Function
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.
Target Involvement
Van der Woude syndrome 1 (VWS1); Popliteal pterygium syndrome (PPS); Non-syndromic orofacial cleft 6 (OFC6)
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
IRF family
Target Tissue Specificity
Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Target Synonyms
Interferon regulatory factor 6; IRF 6; IRF-6; IRF6; IRF6_HUMAN; LPS; OFC 6; OFC6; OTTHUMP00000034677; OTTHUMP00000034678; PIT; PPS; PPS1; VWS; VWS1
Target Background
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
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