Rabbit anti-Human IRF8 Polyclonal Antibody

Uniprot Id

Q02556

Target Species

Human

Target Name

IRF8

Target Full Name

Interferon regulatory factor 8

Target Function

Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection. Positively regulates macroautophagy in dendritic cells.

Target Involvement

Immunodeficiency 32A (IMD32A); Immunodeficiency 32B (IMD32B)

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

IRF family

Target Tissue Specificity

Predominantly expressed in lymphoid tissues.

Target Synonyms

ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP; IRF8

Target Background

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.