Rabbit anti-Human IRF9 Polyclonal Antibody

Uniprot Id

Q00978

Target Species

Human

Target Name

IRF9

Target Full Name

Interferon regulatory factor 9

Target Function

Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Target Protein Families

IRF family

Target Synonyms

p48; IRF-9; ISGF3; ISGF3G; F9

Target Background

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65.