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The antibody against ITSN2 was raised in rabbit using the Recombinant Human Intersectin-2 protein (940-1209AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against ITSN2 was raised in rabbit using the Recombinant Human Intersectin-2 protein (940-1209AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-13699A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ITSN2 |
| Target Synonyms | ITSN2 antibody; KIAA1256 antibody; SH3D1B antibody; SWAP antibody; Intersectin-2 antibody; SH3 domain-containing protein 1B antibody; SH3P18 antibody; SH3P18-like WASP-associated protein antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Intersectin-2 protein (940-1209AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NZM3 |
Uniprot Id
Q9NZM3
Target Species
Human
Target Name
ITSN2
Target Full Name
Intersectin-2
Target Function
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in melanocytes. Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
Target Synonyms
ITSN2; KIAA1256; SH3D1B; SWAP; Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
Target Background
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis.
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