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The antibody against IWS1 was raised in rabbit using the Recombinant Human Protein IWS1 homolog protein (570-819AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against IWS1 was raised in rabbit using the Recombinant Human Protein IWS1 homolog protein (570-819AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human liver tissue using IWS1 Antibody at dilution of 1:100
| Cat.No | ADC-17145A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IWS1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein IWS1 homolog protein (570-819AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96ST2 |
Uniprot Id
Q96ST2
Target Species
Human
Target Name
IWS1
Target Full Name
Protein IWS1 homolog
Target Function
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Target Subcellular Location
Nucleus.
Target Protein Families
IWS1 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
DKFZp761G0123; FLJ10006; FLJ14655; FLJ32319; Interacts with Spt6; iws1; IWS1 homolog; IWS1-like protein; IWS1_HUMAN; IWS1L; MGC126375; MGC126376; OTTHUMP00000162262; Protein IWS1 homolog
Target Background
Involved in regulation of histone modification; regulation of mRNA export from nucleus; and regulation of mRNA processing. Located in nucleoplasm.
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