Rabbit anti-Human JAG1 Polyclonal Antibody

The antibody against JAG1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 34-180 of human JAG1 (NP_000205.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03220A

Number

Cat.No	ADA-03220A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	JAG1
Target Synonyms	AGS; AHD; AWS; HJ1; AGS1; DCHE; CD339; JAGL1; CMT2HH; JAG1	Form	Liquid
Species Reactivity	Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse brain	Application	ELISA, WB

Cat.No

ADA-03220A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

JAG1

Target Synonyms

AGS; AHD; AWS; HJ1; AGS1; DCHE; CD339; JAGL1; CMT2HH; JAG1

Form

Liquid

Species Reactivity

Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse brain

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 34-180 of human JAG1 (NP_000205.1).	Target Species	Human
Immunogen Sequence	QFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFE	Uniprot ID	P78504

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 34-180 of human JAG1 (NP_000205.1).

Target Species

Human

Immunogen Sequence

QFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFE

Uniprot ID

P78504

Background Information

Uniprot Id

P78504
Target Species

Human
Target Name

JAG1
Target Full Name

Protein jagged-1
Target Function

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Target Involvement

Alagille syndrome 1 (ALGS1); Tetralogy of Fallot (TOF)
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Tissue Specificity

Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a wh
Target Synonyms

AGS; AHD; AWS; CD 339; CD339; CD339 antigen; Headturner ; hJ1; Htu; Jag 1; Jag1; JAG1_HUMAN; Jagged 1; Jagged1 (Alagille syndrome) ; Jagged1; JAGL1; MGC104644; OTTHUMP00000030278; Protein jagged-1; Ser 1; Ser1; Serrate 1; Slalom
Target Background

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Rabbit anti-Human JAG1 Polyclonal Antibody

Specifications

Immunogen Information

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