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The antibody against JARID2 was raised in rabbit using the Recombinant Human Protein Jumonji protein (1-159AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against JARID2 was raised in rabbit using the Recombinant Human Protein Jumonji protein (1-159AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human kidney tissue using JARID2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using JARID2 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using JARID2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-15079A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | JARID2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein Jumonji protein (1-159AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q92833 |
Uniprot Id
Q92833
Target Species
Human
Target Name
JARID2
Target Full Name
Protein Jumonji
Target Function
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
Target Synonyms
JARD2; JARD2_HUMAN; JARID2; JMJ; Jumonji AT rich interactive domain 2 ; Jumonji homolog; Jumonji like protein; Jumonji protein; Jumonji/ARID domain containing protein 2; Jumonji/ARID domain-containing protein 2; Protein Jumonji
Target Background
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies.
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