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The antibody against JMJD1C was raised in rabbit using the Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C protein (539-648AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against JMJD1C was raised in rabbit using the Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C protein (539-648AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using JMJD1C Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human melanoma using JMJD1C Antibody at dilution of 1:1002
| Cat.No | ADC-15399A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | JMJD1C |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C protein (539-648AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15652 |
Uniprot Id
Q15652
Target Species
Human
Target Name
JMJD1C
Target Full Name
Probable JmjC domain-containing histone demethylation protein 2C
Target Function
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
Target Subcellular Location
Nucleus.
Target Protein Families
JHDM2 histone demethylase family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
JHD2C_HUMAN; Jmjd1c; Jumonji domain containing 1C ; Jumonji domain-containing protein 1C; Probable JmjC domain-containing histone demethylation protein 2C; Thryoid receptor interacting protein; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; TRIP8
Target Background
The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants.
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