Rabbit anti-Human JPH1 Polyclonal Antibody, Biotin conjugated

Uniprot Id

Q9HDC5

Target Species

Human

Target Name

JPH1

Target Full Name

Junctophilin-1

Target Function

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.

Target Subcellular Location

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein.

Target Protein Families

Junctophilin family

Target Tissue Specificity

Abundantly expressed in skeletal muscle. Very low levels in heart.

Target Synonyms

DKFZp762L0313; JP 1; JP-1; JP1; JPH 1; JPH1; JPH1_HUMAN; Junctophilin 1; Junctophilin type 1; Junctophilin type1; Junctophilin-1; Junctophilin1; Mitsugumin 72; Mitsugumin72

Target Background

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.