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The antibody against JPH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against JPH4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01432A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | JPH4 |
| Target Synonyms | JP4; JPHL1; JPH4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293T, HepG2, HT-1080, Mouse liver, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96JJ6 | Immunogen Sequence |
Uniprot Id
Q96JJ6
Target Species
Human
Target Name
JPH4
Target Full Name
Junctophilin-4
Target Function
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
Target Subcellular Location
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Target Protein Families
Junctophilin family
Target Synonyms
JP-4; Jph4; JPH4_HUMAN; JPHL1; Junctophilin 4; Junctophilin like 1 protein; Junctophilin-4; Junctophilin-like 1 protein; KIAA1831
Target Background
This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants.
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